Assessment of sympathetic neural activity in chronic insomnia: evidence for elevated cardiovascular risk

[摘要] Study ObjectivesChronic insomnia affects up to 15 per cent of adults. Recent cross-sectional and prospective epidemiological studies report an association between insomnia and hypertension, including incident hypertension, yet mechanisms underlying the association remain unknown. We hypothesized that participants with chronic insomnia would have elevated sympathetic neural outflow, blunted baroreflex sensitivity, and augmented sympathetic neural and cardiovascular reactivity to stress when compared with good-sleeper controls.

[学科分类] 生理学

[关键词] primary insomnia;hyperarousal;sympathetic nervous system;baroreflex;hypertension;sleep disorder