Brain-derived erythropoietin protects from intermittent hypoxia-induced cardiorespiratory dysfunction and oxidative stress in mice

[摘要] Study ObjectivesBased on the fact that erythropoietin (Epo) administration in rodents protects against spatial learning and cognitive deficits induced by chronic intermittent hypoxia (CIH)–mediated oxidative damage, here we tested the hypothesis that Epo in the brain protects against cardiorespiratory disorders and oxidative stress induced by CIH in adult mice.

[学科分类] 生理学

[关键词] respiratory control;brainstem;sleep apnea;oxidative stress;blood pressure;OSA-pharmacotherapy