Precision surgical oncology? The treasure is in the tissue

[摘要] In the era of precision oncology, the molecular biological data derived from patient biospecimens directly influences patient management. For cancer resection specimens, traditional types of specimen-derived data, such as tumor type, grade, pathological stage, and resection margin status, also are essential and must be accurately reported; however, these data are derived from histopathological observation and are rarely significantly compromised by preanalytical variables in the biospecimen “life cycle” (see Figure 1). Therefore, little, if any, attention needed to be directed toward the standardization, control, and tracking of preanalytical variables. With molecular assessment now standard for many cancers and increasingly required for many others, the bar for the molecular quality of cancer biospecimens has gone up and has given preanalytics a much greater level of significance.

[学科分类] 外科医学