Characterization and modification of porosity in electrospun polymeric materials for tissue engineering applications

[摘要] (cont.) Human Dermal Fibroblasts were seeded into scaffolds of drastically varied fiber diameter (300nm to 8 [mu]m) and morphology (beaded vs. uniform diameter). Despite cells spreading along large fibers instead of developing multiple attachment points between fibers, cell proliferation was greatest in scaffolds with pore diameters greater than 6 [mu]m. At the same time, mats with pore diameters less than 12 pm observed the greatest extracellular matrix growth. Additional investigation would be well-served to determine optimal parameters for cell dispersion and reproduction throughout the electrospun template across multiple cell phenotypes.

[发布机构] Massachusetts Institute of Technology