CONSTRUCTION OF GOLD NANORODS CARRYING IFNγ AND METHIONINE TO TARGET MCF-7 CELLS

[摘要] Development of gold nanoparticles (GNPs) conjugated with interferon gamma (IFNγ) and methionine along with the use of near-infrared (NIR) laser beams for treatment of cancer cells was the main aim of this study. MCF-7 cells were cultured and incubated with conjugated GNPs with IFNγ and methionine at different concentration followed by irradiation with NIR laser beam. Samples were then evaluated for their viability by MTT assay which showed that the GNPs complex was toxic on tumor cells (P<0.05) at 0.64μg/ml concentration. Exposure to hyperthermia decreased the viability of cells significantly at 0.3μg/ml concentration of gold nanorods complex.

[学科分类] 生物技术

[关键词] Hyperthermia;gold nanorods;MCF-7;NIR laser;interferon -gamma.