Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom

[摘要] BackgroundIn recent decades, snake venom disintegrins have received special attention due to their potential use in anticancer therapy. Disintegrins are small and cysteine-rich proteins present in snake venoms and can interact with specific integrins to inhibit their activities in cell-cell and cell-ECM interactions. These molecules, known to inhibit platelet aggregation, are also capable of interacting with certain cancer-related integrins, and may interfere in important processes involved in carcinogenesis. Therefore, disintegrin from Crotalus durissus collilineatus venom was isolated, structurally characterized and evaluated for its toxicity and ability to interfere with cell proliferation and migration in MDA-MB-231, a human breast cancer cell line.

[学科分类] 过敏症与临床免疫学

[关键词] Crotalus durissus collilineatus;Non-RGD disintegrin;Cell migration;Cell adhesion;Human breast cancer;MDA-MB-231