Injectable nanocurcumin-dispersed gelatin–pluronic nanocomposite hydrogel platform for burn wound treatment

[摘要] To utilize the potent pharmaceutical properties of curcumin (Cur) and gelatin-based materials in tissue regeneration, we fabricated a thermosensitive nanocomposite hydrogel based on pluronic-grafted gelatin (PG) and nanocurcumin (nCur) to enhance burn healing. In this method, the amphiphilic PG played a role as a surfactant to prepare and protect nanosized Cur particles, which could overcome the poor dissolution of the phytochemical. The synthesized PG was identified by ${}^1$H nuclear magnetic resonance. Depending on the amount of Cur, size distribution of the dispersed nCur ranged from $1.5\pm 0.5$to $16\pm 3.2$ nm as observed using transmission electron microscopy and dynamic light scattering. The nCur-dispersed PG solution formed nCur–PG nanocomposite hydrogel on warming up to 35$^{\circ}$C. Release profile indicated sustainable release of Cur from the injectable platform. Fibroblast cells were well proliferated on the nanocomposite hydrogel. The nCur–PGenhanced the healing process of second-degree burn wound. These results showed potential applications of the biomaterial in tissue regeneration.

[学科分类] 材料工程

[关键词] Nanocurcumin;gelatin;pluronic F127;nanocomposite hydrogel;wound healing.