NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes

[摘要] BackgroundAstrocytes maintain central nerve system homeostasis and are relatively resistant to cell death. Dysfunction of cell death mechanisms may underlie glioblastoma genesis and resistance to cancer therapy; therefore more detailed understanding of astrocytic death modalities is needed in order to design effective therapy. The purpose of this study was to determine the effect of VAS2870, a pan-NADPH oxidase inhibitor, on staurosporine-induced cell death in astrocytes.

[学科分类] 肿瘤学

[关键词] astrocytes;VAS2870;mitochondrial potential;ATP;reactive oxygen species;cell death