The effects of two bone substitute materials in the treatment of experimentally induced mandibular defects:An experimental study

[摘要] Aims: To compare between the effects of deproteinized bovine bone (DBB) and osteon in thehealingof mandibular bone defects in the rabbits. Materials and Methods: This experimental study was conductedon ten rabbitsat the Animal House, Dentistry college, Mosul University. Therabbits weighted between 1.5 and 2 kg and each rabbit was given anesthesia (10% ketamine (40 mg/kg) and 2% xylazine (5 mg/kg). Surgery was performed aseptically. Mandibles were exposed through a sub-mandibular incisions. Three rectangular full thickness defects (6×5 mm) were created in each side. The firstdefect in each side was filled with DBB, the second defect was filled with osteon, while the third defectwas left untreated to serve asa control.Five rabbits were sacrificed after one week and the other five rabbits were sacrificed after one month. The bony mandibles were immersed in 10% formalin solution and examined histologically by two histopathologists. Results: Microscopically, sections for one week of all groups showedmild degree of inflammation, moderate amount of vascularity, granulation tissue and osteoidtissue formation. Sections of one month showedno difference regarding the degree of inflammation vascularity, but the amount of granulation tissueand osteoidtissue formation in the control group were lesser than the amount seen in both experimental groups. Conclusions:DBB and osteon accelerate bone healing after month regarding the amount of granulation tissue and osteoidtissue formation.

[学科分类] 口腔科学

[关键词] Deproteinized bovine bone