ЭКСПРЕССИЯ ПРО- И ПРОТИВОВОСПАЛИТЕЛЬНЫХ ФАКТОРОВ ПРИ ФЕМТОСЕКУНДНОМ ЛАЗЕРНОМ СОПРОВОЖДЕНИИ ФАКОЭМУЛЬСИФИКАЦИИ НА ФОНЕ ПРИМЕНЕНИЯ РАЗЛИЧНЫХ НЕСТЕРОИДНЫХ ПРОТИВОВОСПАЛИТЕЛЬНЫХ СРЕДСТВ

[摘要] Purpose. To  perform  a  comparative  analysis  of  11  cytokines concentration after femtosecond laser-assisted phacoemulsification (FLACS) and  before  conventional  phacoemulsification  (CPE)  with  preoperative instillations of various nonsteroidal anti-inflammatory drugs (NSAID). Material and methods . Prospective single center study was carried out. Aqueous humor samples were obtained in 24 patients immediately after FLACS or before CPE. Preoperatively in the first and second groups(FLACS) the patients were administered (QD and QID) with either topical bromfenac 0.09% (group I, 12 eyes) or indomethacin 0.1% (group II, 12 eyes). In two control (CPE) groups the same regimen of instillations of NSAIDs was used. The samples were aspirated from the anterior chamber through paracenthesis right at the beginning of the surgery. The analysis of cytokines was performed with the FlowCytomics FC 500 Pro 3.0 Software (Bender MedSystems). Results.An increase of IL-6 in the group I was revealed as compared with the group III, p<0.05. In the analysis of IL-6 in the group II, there were no statistically significant differences compared to the group IV. The construction of correlation networks with the establishment of a correlation coefficient threshold >0.7, revealed the absence of correlation dependence of IL-6 in relation to other cytokines in the group I. In the group II, there was the correlation relationship between IL-6 and the network of cytokines. In the groups III and IV the IL-6 had no correlation to cytokine network. Conclusion.NSAIDs may not be effective in neutralizing the activation of IL-6 in some cases. In particular, it was found that indomethacin 0.1% compared with bromfenac 0.09% has the lowest activity in neutralizing IL-6 and switching it off from the correlation network at a threshold of the correlation coefficient of >0.7.

[学科分类] 眼科学

[关键词] femtosecond laser-assisted phacoemulsification;cataract;cytokines;correlation networks.;фемтосекундное сопровождение факоэмульсификации;катаракта;цитокины;корреляционные сети