Сравнительная эффективность хирургического лечения макулярных разрывов с применением богатой тромбоцитами плазмы крови

[摘要] Purpose . Evaluation of the results of treatment of idiopathic macular holes (MH) with the use of autologous platelet-rich plasma (PRP) in comparison with standard technology in terms of up to 12 months.Material and methods . We examined 62 people (66 eyes) with MH, operated by two highly skilled surgeons, with application of PRP on the MH (the main group). The control group consisted of 165 patients (173 eyes) operated by the same surgeons in 2010-14 by standard technology.Results . The compared groups did not differ in age-sex characteristics, axial length of the eye, hole duration. Parameters of the MH and foveal region were significantly worse in the main group compared to the control group; in particular, the minimum diameter of the hole was 445±184 μm vs. 376±149 μm. Despite this, the anatomical and functional results of the treatment in the main group were significantly better than in the control group. In all patients of the main group, it was possible to achieve complete closure of the hole, while in the control group the hole was not blocked in 14 eyes (P=0.013). Measured 12 months after surgery, the median increase in visual acuity was almost 9 ETDRS letters greater in the main group (P=0.012).Conclusion . The use of PRP significantly improves the anatomical and functional results of treatment of idiopathic MH, including MH of large diameter and with an unfa vorable prognosis for standard surgery. 

[学科分类] 眼科学

[关键词] idiopathic macular hole;platelet-rich plasma;anatomical outcome;visual acuity;dynamics;идиопатический макулярный разрыв;богатая тромбоцитами плазма;анатомический исход;острота зрения;динамика