ConcomitantKRASandBRAFmutations in colorectal cancer

[摘要] BRAFandKRASare two key oncogenes in the RAS/RAF/MEK/MAP-kinase signaling pathway. While previously considered mutually exclusive, concomitant mutations in bothKRASandBRAFgenes have been identified in colorectal cancer (CRC). The clinical outcome of these patients remains undetermined. We present the clinical course of two patients with CRC harboring mutations at codon 12 ofKRASandBRAFnon-V600E mutations. More research is needed to determine the clinical-pathological effect of these simultaneous mutations ofKRASandBRAFin CRC on disease course and treatment outcome.

[学科分类] 肿瘤学