Total compared with partial pancreatectomy for pancreatic adenocarcinoma: assessment of resection margin, readmission rate, and survival from the U.S. National Cancer Database

[摘要] IntroductionTotal pancreatectomy for pancreatic ductal adenocarcinoma has historically been associated with substantial patient morbidity and mortality. Given advancements in perioperative and postoperative care, evaluation of the surgical treatment options for pancreatic adenocarcinoma should consider patient outcomes and long-term survival for total pancreatectomy compared with partial pancreatectomy. MethodsThe U.S. National Cancer Database was queried for patients undergoing total pancreatectomy or partial pancreatectomy for pancreatic adenocarcinoma during 1998–2006. Demographics, tumour characteristics, operative outcomes, 30-day mortality, 30-day readmission, additional treatment, and Kaplan–Meier survival curves were compared. ResultsThe database query returned 807 patients who underwent total pancreatectomy and 5840 who underwent partial pancreatectomy. More patients who underwent total pancreatectomy than a partial pancreatectomy had a margin-negative resection ( p< 0.0001). Mortality and readmission rates were similar in the two groups, as was longterm survival on Kaplan–Meier curves ( p= 0.377). A statistically significant difference in the rate of surgery only (without additional treatment) was observed for patients in the total pancreatectomy group ( p= 0.0003). ConclusionsAlthough total compared with partial pancreatectomy was associated with a higher rate of marginnegative resection, median survival was not significantly different for patients undergoing either procedure. Patients who underwent total pancreatectomy were significantly less likely to receive adjuvant therapy.

[学科分类] 肿瘤学

[关键词] Pancreatectomy;pancreaticoduodenectomy;pancreatic neoplasms;morbidity;mortality;database;postoperative care