Rifampin Induced Acute Tubulo-interstitial Nephritis: Rare Event of Commonly Used Drug

[摘要] Background: Interstitial nephritis, complication of anti-tubercular therapy has been most commonly reported due to rifampin therapy. The mechanism of rifampin-induced acute kidney injury is either a type II or type III hypersensitivity reaction induced by rifampin antigens in which anti-rifampin antibodies form immune complexes that are deposited in renal vessels, the glomerular endothelium, and the interstitial area. Case Report: We describe a case of 57-year-old man with rheumatoid arthritis who developed acute kidney injury with prominent tubular dysfunction after starting anti-tubercular therapy containing rifampin. Conclusion: Acute tubulo-interstitial nephritis should be included in the differential diagnosis in acute kidney injury and renal tubular damage following rifampin initiation.

[学科分类] 生理学

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