Sodium Valproate as a Probable Cause of Gut Gangrene: Report of TwoUnusual Cases

[摘要] Background: Gangrenous gut is a highly fatal condition most often caused by mesenteric ischemia or intestinal obstruction and requires emergency surgical intervention. There is no definite evidence about role of anti-epileptics as a cause of gut gangrene. Case Report: We encountered two patients who presented with gangrenous bowel and both patients had history of treatment of sodium valproate. There was no other evident cause for gut gangrene in these patients. Conclusion: Hence, with this case report we discuss and emphasize that sodium valproate can be a probable cause for gut gangrene in patients who are undergoing treatment with this agent.

[学科分类] 生理学

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