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A turn-on near-infrared fluorescent probe with rapid response and large Stokes shift for the selective and sensitive detection of zinc(II) and its application in living cells
[摘要] Herein, a new near-infrared turn-on fluorescent probe, YPT, was designed and synthesized for the rapid detection of Zn2+, which exhibited low limit of detection for Zn2+ (12 nM) as well as a favorable large Stokes shift (λem − λex = 168 nm). In addition, the probe showed rapid detection progress within 30 s, accompanied by a distinct change in fluorescence from colorless to bright red. Moreover, the sensing mechanism of YPT towards Zn2+ was supported by the Job's plot, HR-MS analysis, 1H NMR titration analysis and density functional theory (DFT) results. In addition, YPT was applied as a visible test strip for the detection of Zn2+. Finally, the NIR fluorescence imaging of Zn2+ was successfully performed in living cells using this probe. All the results indicate that this probe can be used to detect Zn2+ in both solution and living systems.
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[效力级别]  [学科分类] 分析化学
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