已收录 272993 条政策
 政策提纲
  • 暂无提纲
A protein amantadine-BODIPY assembly as a turn-on sensor for free copper(II)
[摘要] Copper ions are widely found in the environment and food. Free Cu(II) and Cu2+–protein complexes show different functions and toxicities. For example, the increase of free copper ions in the body can cause nervous system dysfunction, and liver and kidney damage. To develop a method for detection of free copper ions in biological tissues, an amantadine-conjugated 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) compound (BOD-Ad) was synthesized. It is found that BOD-Ad can self-assemble with BSA forming non-emissive nanoparticles (BOD-Ad@BSA). Copper(II) induced the release of BOD-Ad from BOD-Ad@BSA with recovered fluorescence emission. Therefore, BOD-Ad@BSA can distinguish free copper(II) from protein–copper(II) complexes. Therefore, BOD-Ad@BSA is a turn-on fluorescent probe for free copper(II). Furthermore, BOD-Ad@BSA was used for the detection of the free Cu2+ content in fish samples bought from a supermarket.
[发布日期]  [发布机构] 
[效力级别]  [学科分类] 分析化学
[关键词]  [时效性] 
   浏览次数:2      统一登录查看全文      激活码登录查看全文