Influence of Deuterium-Depleted Water on Hepatorenal Toxicity

[摘要] The objective of the current study was to evaluate the influence of deuterium-depleted water (DDW) consumption on healthy animals and animals with hepatorenal toxicity. The influence of deuterium-depleted water on hepatorenal toxicity was investigated in Wistar rats. Deuterium-depleted water consumption during 42 days caused changes in isotopic D/H composition of rats’ plasma and lyophilized tissues of internal organs (liver and kidney). Moreover, deuterium-depleted water influenced plasma biochemical parameters. Concentration of creatinine and bilirubin, as well as aspartate aminotransferase and alanine aminotransferase activities were reduced in plasma of rats with hepatorenal toxicity. Deuterium-depleted water consumption during 42 days influenced the body and internal organ weights while integral index of chronic intoxication did not increase in rats with chronic intoxication. It was also revealed that deuterium-depleted water consumption did not display any toxic effects.

[学科分类] 药理学

[关键词] Influence of Deuterium-Depleted Water on Hepatorenal Toxicity;Hepatorenal Toxicity;Deuterium;Liver;Detoxification;NMR Spectroscopy;Isotopes;Plasma;Water;articles;69557