Genotoxicity of mycotoxins in an improved drosophila wing spot test and other short-term effects

[摘要] Attempts have been made recently to improve the Drosophiia SomaticMutation and Recombination wing spot test (SMART) by inciudjig insecticideresistance genes that confer high bioactivation (HB) to SMART tester strains.A drawback of the HB lines is the presence of whorling of wing hairs whichinterferes with scoring for mutant spots. The gene responsible for this whorlingeffect, which I have named paisley (ply), was shown to be recessive andlocated around position 90 on chromosome 2 and is thus linked to the RI generesponsible for the high constitutive expression of cytochrome P450-dependent activities typical of HB strains. (Abbreviation abstract)

[发布机构] University of the Witwatersrand