The economic and ethical considerations and implications of the stratification of future oncology therapeutics

[摘要] (cont.) The aim of this model is to investigate how factors such as pricing, drug efficacy and biomarker accuracy, amongst other factors, impact the patient population, and therefore market size and economic performance for a drug with an associated biomarker. This body of analysis is then used to conduct a second set of interviews with representatives from patient advocacy groups to gauge their opinions on the ethical implications arising out of the economic considerations discussed in the first half of this thesis. In summary, this thesis undertakes a comprehensive review of the history of the adoption of stratified medicine within oncological therapeutics, and a forward-looking analysis of the economic and ethical implications with the aim of clarifying the circumstances in which stratification may be appropriate. In doing so, this thesis provides a resource to pharmaceutical companies and patient advocates attempting to chart a viable path forward in this rapidly changing field.

[发布机构] Massachusetts Institute of Technology