Association of HLA-B38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients

[摘要] Background. HLA-B3802 has been shown to be associated with antithyroid drug-induced agranulocytosis in Asian patients. Methods. HLA-B3802 was analyzed by sequence-based typing in 21 patients who developed antithyroid drug-induced agranulocytosis and in 81 controls. Results. Frequency of HLA-B3802 was 52.4% in agranulocytosis patients compared to 3.7% in controls (OR = 28.6, 95% CI = 6.8–120.2). Conclusions. HLA-B3802 is a significant risk factor for agranulocytosis in Kinh Vietnamese patients treated with antithyroid drug.

[学科分类] 内分泌与代谢学