Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma

[摘要] Our aim was to evaluate the impact of gender on the predictive factors of central compartment lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC). A retrospective study of 590 patients treated for PTC was performed. Univariate and multivariate analyses showed that gender (female; ), age (≥45 y; ), tumor size (>1 cm; ), and multifocality () were independent predictive factors of CLNM in PTC patients. Patients were divided into male group () and female group (). Age (≥45 y; ), T4 () and multifocality () were independent predictive risk factors of CLNM in male patients. As for female patients, age (≥45 y; ), tumor size (>1 cm; ), multifocality (), and microcalcification () were independently correlated with CLNM. The sensitivity of the multivariate model for predicting CLNM in male patients was 64.9%, specificity was 82.9%, and area under the ROC curve (AUC) was 0.764. As for female patients, the sensitivity was 55.7%, specificity was 77.9%, and AUC was 0.73. This study showed that the predictive factors of CLNM indeed varied according to gender. To have a more accurate evaluation of CLNM, different predictive systems should be used for male and female patients.

[学科分类] 内分泌与代谢学