Computational approaches to modeling the conserved structural core among distantly homologous proteins

[摘要] (cont.) From this template, SMURF constructs a Markov random field that combines a profile hidden Markov model together with pairwise residue preferences of the type introduced by BetaWrapPro. The efficacy of SMURF is demonstrated on three beta-propeller fold classes.

[发布机构] Massachusetts Institute of Technology