Cyclic compressive loading on 3D tissue of human synovial fibroblasts upregulates prostaglandin E2 via COX-2 production without IL-1β and TNF-α

[摘要] ObjectiveExcessive mechanical stress on synovial joints causes osteoarthritis (OA) and results in the production of prostaglandin E2 (PGE2), a key molecule in arthritis, by synovial fibroblasts. However, the relationship between arthritis-related molecule

[学科分类] 骨科学

[关键词] Mechanical stress;Osteoarthritis;3-D culture;Synovial fibroblast;Prostaglandin E2