Can zinc protect cells from the cytotoxic effects of cobalt ions and nanoparticles derived from metal-on-metal joint arthroplasties?

[摘要] Objectives Recently, high failure rates of metal-on-metal (MOM) hip implants have raised concerns of cobalt toxicity. Adverse reactions occur to cobalt nanoparticles (CoNPs) and cobalt ions (Co2+) during wear of MOM hip implants, but the toxic mechanism i

[学科分类] 骨科学

[关键词] Cobalt cytotoxicity;Protective effects;Zinc;Cobalt nanoparticles;Cobalt ions