Bone morphogenetic protein-2 provokes interleukin-18-induced human intervertebral disc degeneration

[摘要] ObjectivesInterleukin 18 (IL-18) is a regulatory cytokine that degrades the disc matrix. Bone morphogenetic protein-2 (BMP-2) stimulates synthesis of the disc extracellular matrix. However, the combined effects of BMP-2 and IL-18 on human intervertebral d

[学科分类] 骨科学

[关键词] Bone morphogenetic protein-2 (BMP-2);Interleukin-18 (IL-18);Nucleus pulposus and annulus fibrosus cells;Intervertebral disc degeneration (IVD)