Wnt signaling in granulosa cell tumors of the ovary

[摘要] Granulosa cell tumors (GCT), a malignant type of sex-cord stromal tumor, account for approximately 2-5% of all ovarian malignancies.They are often identified before they have spread beyond the ovary, but advanced disease can be quite challenging to treat.Wnt signaling has been suggested to contribute to the formation of GCT.We hypothesized Wnt signaling was involved in human GCT.

[学科分类] 妇产科学

[关键词] Granulosa cell tumor;ovarian neoplasms;Wnt signaling