Cardiac tissue engineering

[摘要] In this review, we will discuss the current developments in the field of cardiac tissue engineering, with a focus on the studies over the past 5 years. The key advances in cardiac tissue engineering include the generation of human cardiomyocytes from embryonic stem cells and induced pluripotent stem cells, the development of biomaterials that have native tissue-matched mechanical properties, embedded topographical cues and angiogenic factors, as well as the application of physiologic conditions such as perfusion, electrical stimulation and mechanical stretching during cultivation. We will also provide an overview of the recent vascularization approaches applied to cardiac tissue engineering that yielded functional cardiac tissues with physiologically relevant thickness and cell density.

[学科分类] 工业化学