Design considerations of polymeric nanoparticle micelles for chemotherapeutic delivery

[摘要] To improve safety and efficacy of anti-cancer therapy, drug-loaded polymeric nanoparticle micelle systems have been designed to target tumour pathophysiology. To accomplish this, nanoparticles take advantage of enhanced permeability and retention (EPR) of macromolecules to target tumours on a tissue level (passive targeting) while conjugated targeting ligands bind cancer surface markers and promote nanoparticle uptake (active targeting). Composition, size, shape, drug loading, and ligand density are all tunable design parameters that impact nanoparticle targeting. Understanding the complex interplay between these parameters and the resulting effects on drug targeting rationalizes adjustments to nanoparticle formulations.

[学科分类] 工业化学