Regulation of Overnutrition-Induced Cardiac Inflammatory Mechanisms by nebivolol

[摘要] Abstract Background: Unlike conventional -blockers, nebivolol, a third-generation -adrenergic receptor blocker with vasodilator properties, promotes insulin sensitivity. Objective: The objective of this study was to determine whether nebivolol regulates overnutrition-induced activation of cardiac nutrient sensor kinases and inflammatory signaling. Methods: Young Zucker obese (ZO) rats, a rodent model for overnutrition, and age-matched Zucker lean rats were treated with nebivolol (10 mg/kg/day; 2.

[学科分类] 心脏病和心血管学

[关键词] mTORC1;Jak/STAT;Nebivolol;Zucker obese;AMP kinase