The detection of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol in human dried blood spots
[摘要] Phosphatidylethanol,aseriesofabnormalphospholipidsformedinthepresenceofethanolandphospholipaseD,hasgainedpopularityasalong-termbiomarkerofethanolingestion.Aliquidchromatographytandemmassspectrometricmethodforaspecific,prevalentisomer,1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol,wasdevelopedandvalidatedusingdriedbloodspots.Driedbloodspotsoffernumerousadvantagesovervenipunctureincludingreducedcosts,invasivenessanddiscomfort.Driedbloodspotswerepreparedfromauthenticwholebloodspecimensthathadbeentestedusingapreviouslypublishedprocedure.Comparisonoftheresultsfromthetwoassaysdemonstratedexcellentcorrelation.Thedatasuggestthatdriedbloodspotsmaybeausefultoolforthedetectionofalcoholabuseandabstinencemonitoring...
[发布日期] [发布机构]
[效力级别] [学科分类] 分析化学
[关键词] [时效性]
