In situ analysis of [8-13C-7-15N]-double-labelled theophylline by a triple resonance NMR technique

[摘要] [8-13C-7-15N]-labelled theophylline was synthesized and applied for in situ analysis using a 1H–{13C–15N} triple resonance NMR technique. The triple resonance analysis enabled selective detection of labelled theophylline in a mixture containing excess amino acids or crude mouse liver extract, where conventional 1H NMR analysis suffers from difficulty because of background signals...

[学科分类] 分析化学