Identification of counterfeit medicines from the Internet and the World market using near-infrared spectroscopy
[摘要] Pharmaceuticalcounterfeitingisalifethreateningproblemaffectingallcountries.CounterfeitmedicinesmaybeencounteredanywhereinconventionalmarketsorfromtheInternet.Thispaperproposesarapidandnon-destructivenear-infraredspectroscopicmethodfortheidentificationofcounterfeitmedicinesusingtheminimumnumberofauthenticsamples.Aslittleastwentyspectrafromtentabletsfromabatcharerequiredtocompareatestsampletoitsauthenticcounterpart.Inthisrespect,tabletsaremeasuredasreceivedandthecorrelationcoefficientoftheSNV-D2spectrabetweentheauthenticsampleandthetestsampleisdetermined.Acorrelationcoefficientoflowerthan0.95indicatesthatthebatchfailsidentification.Inthiscase,ifenoughauthenticsamplesareavailable,principalcomponentanalysis(PCA)couldbeapplied.ThePCAscoresplotoftheauthenticandcounterfeitsampleswiththe95%equalfrequencyellipsesdrawnaroundtheauthenticsamplesetiseffectiveinidentifyingcounterfeits.Themethodcouldidentify82knowncounterfeitmedicinesoutof201medicinessuppliedfromtheInternetandtheWorldmarket.However,itisstillacomparativemethodtoidentifypotentialcounterfeitsandcannotidentifyproductswithoutauthenticsamples...
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[效力级别] [学科分类] 分析化学
[关键词] [时效性]
