Diffusion-edited NMR spectra of heparin contaminants
[摘要] DiffusionNMRisausefulmethodfortheanalysisofmixtures,providinginformationaboutthenumberofcomponentsaswellasinsightintotheirrelativesizes.Thisworkexplorestheuseofdiffusion-editedNMRmeasurementsfortheidentificationoftheglycosaminoglycanimpuritiesdermatansulfate(DS),chondroitinsulfate(CS),andoversulfatedchondroitinsulfate(OSCS)insolutionsofheparinsubjectedtoenzymaticdigestion.Enzymaticdigestionsignificantlyimprovestheresolutionofthebiopolymerimpuritiesindiffusion-edited1HNMRspectrafacilitatingidentificationofhighmolecularweightcontaminants...
[发布日期] [发布机构]
[效力级别] [学科分类] 分析化学
[关键词] [时效性]
