CRIg mediates early Kupffer cell responses to adenovirus
[摘要] Whereasadenoviralvectorsareknowntoactivatethecomplementcascade,leadingtofixationofC3proteinstotheviralcapsid,theconsequencesofthisactivationforviralclearancefromthecirculationarenotknown.LiverKCs,themacrophagepopulationresponsibleforearlyuptakeandeliminationofmanyblood‐bornepathogens,expressCRIg,acomplementreceptorforC3proteins.Here,wefindthatCRIgisimportantfortheearlyeliminationofC3‐coatedadenoviralvectorsfromthesinusoidalbloodstreambyKCs.Wefurtherdemonstratethatbyactingasacriticalreceptorforadenovirusphagocytosis,CRIgplaysanimportantroleinregulatingvirus‐inducedKCdeathanddepletionofthesecellsfromtheliversinusoidallumen.OurstudythusidentifiesacriticalpathwayregulatingKCfunctionandsurvivalinresponsetosystemicviralinfection...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] complement;phagocytosis;liver sinusoidal endothelial cell;Intravital microscopy;cell death;innate immunity;infection [时效性]
