The role of EMMPRIN in T cell biology and immunological diseases
[摘要] EMMPRIN(CD147),originallydescribedasaninduceroftheexpressionofMMPs,hasgainedattentioninitsinvolvementinvariousimmunologicdiseases,suchthatanti‐EMMPRINantibodiesareconsideredaspotentialtherapeuticmedications.GiventhatMMPsareinvolvedinthepathogenesisofvariousdiseasestates,itisrelevantthattargetinganupstreaminducerwouldmakeforaneffectivetherapeuticstrategy.Additionally,EMMPRINisnowappreciatedtohavemultiplerolesapartfromMMPinduction,includingincellularfunctions,suchasmigration,adhesion,invasion,energymetabolism,aswellasTcellactivationandproliferation.Here,wereviewwhatisknownaboutEMMPRINinnumerousimmunologic/inflammatorydiseaseconditionswithaparticularfocusonitscomplexrolesinTcellbiology...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] T cell activation;proliferation;migration;invasion;adhesion [时效性]
