Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa
[摘要] Inthismini‐review,wewilldiscussrecentfindingsthatimplicateneutrophilinfiltrationandfunctioninestablishingametabolicenvironmenttofacilitateefficientpathogenclearance.Fordecades,neutrophilshavebeenregardedasshortlived,nonspecificgranulocytes,equippedwithtoxicantimicrobialfactorsandarespiratoryburstgeneratingROS.RecentfindingsdemonstratetheimportanceofHIFsignalinginleukocytesandsurroundingtissuesduringinflammation.Here,wewillreviewthepotentialmechanismsandoutcomesofHIFstabilizationwithintheintestinalmucosa...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] inflammation;infection;colitis;epithelium;hypoxia [时效性]
