Recent findings on the role of natural killer cells in the pathogenesis of systemic lupus erythematosus
[摘要] Systemiclupuserythematosusisachronic,multifactorialautoimmunediseaseofcomplexetiology,characterizedbylossoftolerancetonuclearautoantigens,expansionofautoreactiveTandBcellclones,polyclonalBcellactivationthatgivesrisetohypergammaglobulinemia,andincreasedautoantibodyproduction,aswellasimmunecomplexdepositionandmultiorgantissueinflammation.Asdiseaseprogresses,immunecells,mainlyTcellsandmacrophages,infiltrateaffectedorgansandamplifythelocalinflammatoryresponse.Naturalkillercellsarelarge,granularlymphocytesthatareanimportantlinkbetweentheinnateandadaptiveimmunesystems;variationsintheiractivitycorrelatewithseveralautoimmunediseases.Todate,theliteraturehasdisregardednaturalkillercellsasrelevantmodulatorsinsystemiclupuserythematosuspathogenesis,asthesecellsarefewinnumberandshowadysfunctionalphenotypeinpatientswithactivesystemiclupuserythematosus.Thisreviewfocusesonresearchthatcouldhelpdefinetheroleofnaturalkillercellsinsystemiclupuserythematosusandtheirfunctioninregulatingthisautoimmunedisorderinnonlymphoidorgans...
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[关键词] SLE;autoimmunity;MRL/MpJ;PBMC;MRL/MpJlpr;Lupus nephritis [时效性]
