γδ T Cells and dendritic cells in refractory Lyme arthritis
[摘要] Lymediseaseisamultisysteminfectiontransmittedbytickvectorswithanincidenceofupto300,000individuals/yrintheUnitedStates.Theprimarytreatmentsareoralori.v.antibiotics.Despitetreatment,someindividualsdonotrecoverandhaveprolongedsymptomsaffectingmultipleorgans,includingthenervoussystemandconnectivetissues.InflammatoryarthritisisacommonsymptomassociatedwithLymepathology.Inthepastdecades,γδTcellshaveemergedascandidatesthatcontributetothetransitionfrominnatetoadaptiveresponses.ThesecellsarealsodifferentiallyregulatedwithinthesynoviaofpatientsaffectedbyRLA.Here,wereviewanddiscusspotentialcellularmechanismsinvolvingγδTcellsandDCsinRLA.TLRsignalingandantigenprocessingandpresentationwillbethekeyconceptsthatwereviewinaidofunderstandingtheimpactofγδTcellsinRLA...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] Fas;Toll‐like receptor;polyarthritis;caspase;Cd1;CLIP [时效性]
