Regioselectivities in Fe(III)‐catalyzed Cycloisomerization Reactions of γ‐Allenyl Alcohols

[摘要] Iron‐catalyzed intramolecular hydroalkoxylation reactions of allenes were performed to provide various tetrahydrofurans by regioselective 5‐exo cyclization pathway, as the Lewis acidic activation of Fe(III) salts toward unsaturated CC bonds, allenes and alkenes. Cyclohexyl substituted allenes especially isomerized to dienes at a rapid rate, which underwent a competing 6‐endo cyclization mode. The plausible mechanism was presented by experimental results of the reaction intermediates and computational study of Fe‐allene and Fe‐diene complexes.

[学科分类] 化学（综合）

[关键词] Iron catalyst;Allene;Cyclization;Isomerization;Tetrahydrofuran