Diversification of Indoles via Microwave‐assisted Ligand‐free Copper‐catalyzed N‐Arylation

[摘要] A simple, efficient Cu2O catalyst system under microwave irradiation was developed for N‐arylation of various indoles without ligands and additives. Diverse N‐heteroarylated indoles were prepared by coupling indoles with various heteroaryl halides within 1 h. The selective reactivity of bromoindole with aryl iodide provided N‐aryl bromoindoles, which could be useful intermediates for palladium‐catalyzed Heck and Suzuki coupling reactions.

[学科分类] 化学（综合）

[关键词] Microwave;Ligand‐free; Cu2O Indole;N‐arylation