Dysfunction of the ubiquitin-proteasome system in atherosclerotic cardiovascular disease

[摘要] The ubiquitin-proteasome system (UPS) is an integral part of the protein metabolism and protein quality control in eukaryotic cells. It is involved in a number of biological processes of significance for vascular biology and pathology such as oxidative stress, inflammation, foam cell formation, and apoptosis. This review summarizes both indirect and direct lines of evidence for a role of the UPS in atherosclerosis from the initiation to the progression and complication stage and concludes with a future perspective.

[学科分类] 心脏病和心血管学

[关键词] Atherosclerosis;inflammation;oxidative stress;proteasome;ubiquitin