Higher fasting glucose levels are associated with reduced circulating angiogenic cell migratory capacity among healthy individuals

[摘要] BackgroundChronic or severe acute elevations in plasma glucose are associated with decreases in the number and function of circulating angiogenic cells (CACs). However, less is known about whether fasting plasma glucose levels (FPG) within the normal or pre-diabetic range among healthy individuals are associated with decreased CAC function. Establishing this relationship is an important step in developing a line of research that may ultimately lead to preventative lifestyle interventions intended to maximize endogenous CAC function and reduce cardiometabolic disease risk.

[学科分类] 心脏病和心血管学

[关键词] Impaired fasting glucose;metabolism;endothelial progenitor cells (EPCs);circulating angiogenic cells (CACs);chemotaxis;chemokinesis;motility;migration;angiogenesis;cardiovascular;pre-diabetic