Nephrin Trafficking beyond the Kidney—Role in Glucose–Stimulated Insulin Secretion in β Cells

[摘要] The Ig superfamily member nephrin is the key structural component of the slit diaphragm, which interconnects neighboring podocyte foot processes in kidney glomerulus. Mutations in the nephrin gene (Nephrotic Syndrome Gene 1 [NPHS1]) cause the congenital nephrotic syndrome of the Finnish type (NPHS1.

[学科分类] 泌尿医学