Evaluate the Effectiveness of Conservative Treatment for Menorrhagia in Women who were Admitted to the Shahid Sadoughi Hospital of Yazd-Iran in 2014-2015
[摘要] Background and aim: Abnormal uterine bleeding is one of the most common debilitatingmenstrual problems. The first therapeutic strategy for abnormal uterinebleeding is drug treatment. This study was, therefore, designed to determinethe efficacy of megestrol, medroxyprogesterone, GnRh agonist, Levonorgestrol IUDand endometrial ablation on bleeding and also to evaluate the side effects ofeach methods in patients with menorrhagia who were admitted to the Shahid Sadoughi clinic of Yazd University of Medical Sciences. Methods and Materials: Based on an analytical study with consideration of patients’ medicalhistory, 89 patients with age range of 25-50 years old were included. Eachpatient, under gynecologist supervision, received one of treatments for threemonth. The evaluation of patients bleeding in response to treatment wereperformed using a check list filled by patients and the results were comparedbefore and after treatment. Medroxyprogesterone acetate, megestrol, GnRhagonist (Triptorelin embonate), Levonorgestrol IUD and endometrial ablation was used for patients astheir characteristics. Each treatment was conducted for a period of 3 months.Megestrol 40 mg per day on an ongoing basis, medroxyprogesterone from 15th dayof menstruation for 10 nights and Diphereline 3.75 mm (manufactured by AriaHealth) were administered every 28 days. Mean of bleeding before and aftertreatment and complications of conservative therapy were evaluated. Statisticalanalysis of the data were performed using paired t test and Wilcoxon tests onspss-19 software. Result: Mean of age was 41.2 (25-50). Megestrol treatment with a frequency of 27% (24patients) and endometrial ablation with a frequency of 20.2% (18 patients) werethe most used therapy in this study. All of these ways of conservativetreatment can decrease bleeding significantly. The complications of thesemethods of treatment were not significantly different. (p=0.37).Satisfaction of women after 2-3 months of treatment wereincreasing because spotting is common in the first months of therapy. Conclusion: The results of this study indicate that all five methods are good enoughto treat menorrhagia. All these methods can replace hysterectomy, especially inthis age range in which preserve fertility is of particular importance, andpatients can also be protected from hysterectomy, a heavy surgery, and surgeryand post surgery complications.
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[效力级别] [学科分类] 分子生物学,细胞生物学和基因
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