BLT2 is a pro-tumorigenic mediator during cancer progression and a therapeutic target for anti-cancer drug development

[摘要] Cancer is a leading cause of death worldwide and has been linked to inflammation. Leukotriene B4 (LTB4) is synthesized from arachidonic acid via the 5-lipoxygenase pathway and is a potent chemoattractant for inflammatory cells. LTB4 was recently shown to be associated with the pathogenesis of inflammatory diseases, including cancer. Of the two known LTB4 receptors, BLT1 and BLT2, the biological roles of the low-affinity LTB4 receptor 2, BLT2, have only recently been elucidated. This review focuses on recent discoveries regarding BLT2 and its roles in cancer progression and the downstream signaling mechanisms of the BLT2-linked signaling cascade in cancer cells. We believe that these findings will facilitate the development of new cancer treatments.

[学科分类] 肿瘤学

[关键词] Leukotriene B4 receptor 2 (BLT2);leukotriene B4;NADPH oxidase;reactive oxygen species;nuclear factor-kB;cancer progression