Co-infection of Epstein-Barr virus and human papillomavirus in human tumorigenesis

[摘要] Viral infections contribute to approximately 12% of cancers worldwide, with the vast majority occurring in developing countries and areas. Two DNA viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV), are associated with 38% of all virus-associated cancers. The probability of one patient infected with these two distinct types of viruses is increasing. Here, we summarize the co-infection of EBV and HPV in human malignancies and address the possible mechanisms for the co-infection of EBV and HPV during tumorigenesis.

[学科分类] 肿瘤学

[关键词] Epstein-Barr virus;Human papillomavirus;Co-infection;Nasopharyngeal carcinoma;Cervical cancer;Breast cancer;Prostate cancer