Impaired Deoxyribonuclease I Activity in Patients with Inflammatory Bowel Diseases

[摘要] Background and Aims. Deoxyribonuclease I (DNaseI) is an endonuclease that facilitates chromatin breakdown and promotes susceptibility to autoimmune disorders. The aim of current study was to investigate serum DNase I activity in patients with inflammatory bowel diseases (IBD). Patients and Methods. A cohort of 110 IBD patients was evaluated, aged 3512 years, 77 with Crohn's disease (CD) and 33 with ulcerative colitis (UC). 50 SLE patients and 50 healthy blood donors were examined as controlgroups.Results. DNase I activity in IBD patients was significantly lower than in healthy individuals, but higher than in SLE patients (). Patients with UC showed higher DNase I activity than CD patients, . DNase I activity in female patients with IBD was significantly lower than in males, ; however, no differences in DNase I activity were found in relation to gender in healthy individuals. DNase I activity has shown a strong negative correlation with the serum concentration of anti-nucleosomal antibodies in the autoimmune (SLE.

[学科分类] 内科医学