Engineering magnetic viral nanoheaters for targeted hyperthermia treatment of cancer

[摘要] Extensive investigations into the multifunctional nature of magnetic nanoparticles have sparked a burgeoning interest in their use for biomedical applications. The potential of abolishing cancer via externally induced hyperthermia has inspired the development of a plethora of systems used to deliver superparamagnetic compounds to cancerous cells while avoiding non-target tissue. The prevailing challenges are: (A) generating particles capable of selectively binding and entering oncolytic targets to generate internal heating and (B) delivering adequate amounts of magnetic particles that generate sufficient heat at clinically acceptable field levels. Adeno-associated virus (AAV) has yet to be exploited as a hyperthermia agent but lends itself well to manipulation as a superparamagnetic nanoparticle since it is genetically encoded and can be precisely engineered to concomitantly meet multiple aims. Specific aims of the project were: (1) endow AAV with superparamagnetic potential through genetic engineering, and (2) target virus-metal nanoparticles to cancer cells through laboratory directed evolution.

[发布机构] Rice University

[效力级别] engineering