GPla Polymorphisms Are Associated with Outcomes in Patients at High Cardiovascular Risk

[摘要] BackgroundPlatelet membrane glycoprotein receptors mediate thrombus formation. GP Ia/IIa is an essential platelet integrin receptor. Single-nucleotide polymorphisms (SNPs) of the GP Ia/IIa gene alter GP Ia/IIa expression; however, their influence on cardiovascular disease remains unclear. This study aimed to investigate the effect of the GP Ia/IIa SNPs rs1126643 and rs1062535 on clinical outcomes in a large collective including high-risk patients with cardiovascular disease.

[学科分类] 心脏病和心血管学

[关键词] integrin alpha2;polymorphism;single nucleotide;thromboembolism;coronary artery disease;clinical study